Thesis Project Description:
Our objective is to construct an advanced nanoscale delivery system combining (i) a member of a recently developed family of macrocyclic molecular containers (cucurbituril or CB as a reference to its pumpkin shape) as a molecular cargo, attached on (ii), targeting peptides with selective recognition abilities toward Low Density Lipoprotein (LDL)-Receptors. The idea is to be able to reach the LDL-R expressed on cell surfaces and internalize, the compounds (drugs and fluorescent tracers) transported by CB, into cells. The challenge lies in the selective targeting of unmodified (efficient) drugs to desired sites of interest for imaging or therapeutic applications. The ability of CB to transport a variety of substances with relevant affinities, and of the designed peptides to reach LDL-Receptors, are expected to tackle this challenge.
Interdisciplinary Research Axis:
Master of Chinese Medicinal Science, University of Macau, China